Citicoline has been used to treat a variety of neurodegenerative disorders, particularly in relation to ischemic stroke, head trauma, age-related cognitive deterioration and Alzheimer’s Disease. 

Exogenous citicoline is hydrolyzed in the small intestine to form choline and cytidine, both of which are easily absorbed and dispersed throughout the organism.

Choline and cytidine can cross the blood brain barrier (BBB), where they are re-synthesized into CDP-choline.